Immunology
It helps to investigate the composition and functions of the organism’s immune system, as well as the fundamental immunological mechanisms underlying related diseases. Currently, the main research directions and hot topics in international immunology include: (1) the conditions and regulatory mechanisms governing the generation, differentiation, and development of immune cells; (2) the mechanisms by which immune cells recognize antigens, become activated, and transmit signals; (3) the cytotoxic mechanisms and functional pathways through which effector immune cells and effector molecules target and kill their respective target cells; (4) the discovery of novel immune cell types and the regulation of their functions; (5) the development, structural analysis, and functional studies of new immune molecules, including cytokines and chemokines; (6) the immune regulatory mechanisms that maintain homeostasis within the immune system—namely, the intricate networks of molecular–molecular, cell–cell, and immune system–system interactions; and (7) the establishment of disease models relevant to immunity and the investigation of their underlying immunological mechanisms. Among these research priorities, cellular super-resolution imaging serves as an essential tool, and the MEAGLE 100 can provide valuable support for such imaging applications.
Case study
In the kidney, resident macrophages and fibroblasts are continuously exposed to environmental stimuli, and age‑related accumulation of cell reprogramming driven by local immune responses may both increase the risk of renal disease in older individuals. Moreover, since chronic kidney disease—particularly end‑stage renal disease—is often accompanied by immune senescence, and many renal disorders are closely linked to aging, therapeutic strategies targeting immune senescence could potentially be translated into clinical interventions for kidney diseases.
Related Cases
Bovine pulmonary artery endothelial cells
Embryonic cells
Canine renal cells
Renal tubular epithelial cells
Retinal cells
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