Pharmacology
It helps elucidate the principles governing drug–organism interactions and the mechanisms underlying drug action. For example, most chemotherapeutic agents exert their anticancer effects primarily by inducing apoptosis in tumor cells; studies have further revealed that many antitumor drugs can also elicit anticancer activity through the induction of paraptosis. These agents include natural products and their derivatives, metal complexes, and conventional chemotherapeutics. They may trigger paraptosis via multiple pathways, such as endoplasmic reticulum stress, mitochondrial swelling, inhibition of proteasome activity, disruption of intracellular ion homeostasis, and activation of the MAPK signaling pathway. The MEAGLE 100 instrument from Changyi Guangke enables precise monitoring of a series of subcellular changes occurring within cells under drug treatment, allowing researchers to investigate the pharmacological properties of drugs by analyzing morphological alterations in these organelles.
Case study
The nucleus is a dynamic, network‑like structure composed of chromatin, RNA, and proteins, playing a crucial role in genome folding and regulation. Mitochondria serve as the cell’s energy‑metabolism hub, with their functions tightly regulated by nuclear activity. Investigating the interplay between these two organelles is essential for elucidating their roles in physiological and pathological processes. Under pharmacological perturbation, both the nucleus and mitochondria undergo distinct morphological changes.
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