Changyi Guangke (Suzhou) Technology Co., Ltd.

Changyi Guangke, headquartered in the Suzhou Industrial Park of the China (Jiangsu) Pilot Free Trade Zone, maintains branch offices in Xi’an and Qingdao. As a high-tech enterprise specializing in micro‑ and nano‑scale optical imaging and the R&D and manufacturing of advanced optical instruments, Changyi Guangke is one of the few domestic manufacturers that independently develops software, hardware, and underlying components across the entire technology stack.

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Laser Confocal Microscope

MEAGLE 320

Laser Confocal Microscope


Super-resolution optical resolution can reach 120 nm. Continuous spectral tuning accuracy can achieve 1 nm. Imaging speed can be as fast as 16 fps. It also supports ultra-high pixel counts of 8192×8192.

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Product Introduction

The MEAGLE 320 is a domestically developed, manufactured, and marketed laser‑scanning confocal microscope from Changyi Guangke, offering an exceptionally cost‑effective alternative to imported confocal systems. It delivers an ultra‑high‑resolution optical resolution of up to 120 nm, with continuous spectral tuning accurate to 1 nm, and achieves imaging speeds of up to 16 frames per second, while supporting an ultra‑high pixel count of 8192 × 8192. Behind the complete domestication of all components and software lies outstanding performance that meets or exceeds the key specifications of leading international brands.

The MEAGLE 320 is equipped with multiple high-precision motion modules, enabling a variety of imaging modes, including motorized focusing, three-dimensional scanning, and automated large-field-of-view stitching. Its post-processing analysis bridges the gap between qualitative and quantitative observations; the system not only offers an extensive suite of post-processing tools—such as deconvolution, image enhancement, image smoothing, morphological processing, and feature segmentation—but also provides advanced scene‑specific analysis capabilities, including cellular statistical analysis, subcellular localization, protein‑protein colocalization, forward and reverse tracking, cell subpopulation classification, and cell tracking.

The MEAGLE 320 is a domestically developed, manufactured, and marketed laser‑scanning confocal microscope from Changyi Guangke, offering an exceptionally cost‑effective alternative to imported confocal systems. It delivers an ultra‑high‑resolution optical resolution of up to 120 nm, with continuous spectral tuning accurate to 1 nm, and achieves imaging speeds of up to 16 frames per second, while supporting an ultra‑high pixel count of 8192 × 8192. Behind the complete domestication of all components and software lies outstanding performance that meets or exceeds the key specifications of leading international brands.

The MEAGLE 320 is equipped with multiple high-precision motion modules, enabling a variety of imaging modes, including motorized focusing, three-dimensional scanning, and automated large-field-of-view stitching. Its post-processing analysis bridges the gap between qualitative and quantitative observations; the system not only offers an extensive suite of post-processing tools—such as deconvolution, image enhancement, image smoothing, morphological processing, and feature segmentation—but also provides advanced scene‑specific analysis capabilities, including cellular statistical analysis, subcellular localization, protein‑protein colocalization, forward and reverse tracking, cell subpopulation classification, and cell tracking.

Laser Confocal Microscope

 

Configuration

Description

Imaging mode

Fluorescence imaging (free combination of X, Y, Z, T, and λ), bright-field imaging, and DIC imaging

Ultra-high resolution

8192*8192 XY: 120 nm Z: 300 nm

Imaging speed

16 frames per second (at 512 × 512), paired with a resonant scanning galvanometer, delivers imaging speeds of up to 32 frames per second.

Excitation light source

405 nm, 445 nm, 488 nm, 520 nm, 561 nm,

639 nm, 785 nm, etc. (standard configuration includes four wavelengths; multiple options available in the upgraded version)

Probe

≥4 PMTs, with ≥2 GaAsP detectors, and a quantum efficiency of ≥45%

Microscopic objective lens

Plan Apochromat Confocal‑Specific Objective Lens

10X: N.A. : 0.4

20X: N.A. : 0.80

40X: N.A.: 0.95

60X: N.A.: 1.42 Oil immersion objective

100X: N.A.: 1.45 Oil immersion objective

Electric focusing

Minimum increment 0.01 μm

Motorized stage

X: ±57 mm Y: ±36.5 mm

Drive speed: 25 mm/s, magnetic sample holder

Microscope main unit

All-electric, research-grade inverted fluorescence microscope

(Nikon Ti2‑E, Olympus Ix83, or a domestically produced option)

Imaging function

Sample two-dimensional imaging, three-dimensional imaging, large-field-of-view mosaic imaging, live-cell time-lapse imaging, and more.
Supports a grating-based spectroscopic system, enabling high-precision, high-linearity spectral scanning, detection, and resolution.

Post-processing function

Deconvolution, 3D reconstruction, image enhancement, colocalization, cell subpopulation classification, AI‑based cell segmentation, cell tracking, and more.

Analysis Function

Interactive measurement functions, automated cell identification, single-cell quantitative analysis, subcellular structure analysis,

Fluorescence colocalization analysis, AI‑based automated analysis and measurement capabilities, and more.

* The processing and analysis software is 100% developed in-house, not third-party software, and can all be installed offline.

* Product performance is continuously being iterated, and customized development requirements for both hardware and software are acceptable. The manufacturer retains the authority to interpret performance parameters.


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Microscope

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