MEAGLE 320-PRO
Laser Confocal Microscope
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Product Introduction
The MEAGLE 320-PRO is a laser‑scanning confocal microscope independently developed and manufactured by Changyi Guangke. It matches the performance specifications of imported confocal systems, offering a high‑performance, cost‑effective alternative among domestic brands. The MEAGLE 320-PRO delivers an ultra‑high resolution of 8192 × 8192 pixels, with a standard imaging speed of 12 fps; when paired with a resonant scanning galvanometer, its frame rate can reach up to 32 fps. Equipped with proprietary algorithms for spectral scanning and spectral unmixing, it achieves continuous spectral tuning with an accuracy of 1 nm. Behind the fully domestically produced components and software lies outstanding performance that meets or exceeds the key benchmarks of leading international brands.
The MEAGLE 320-PRO offers a wide range of imaging modalities, supporting bright-field imaging, wide-field fluorescence imaging, TIRF‑wide-field imaging, and more. It can be optionally equipped with a spinning-disk confocal system and features multiple high‑precision motion stages, enabling motorized focusing, three‑dimensional scanning, and automated large‑field‑of‑view stitching, among other imaging capabilities. Its advanced post‑processing analysis bridges the gap between qualitative and quantitative observations; the system provides an extensive suite of post‑processing tools, including deconvolution, image enhancement, image smoothing, morphological processing, and feature segmentation, while also offering specialized analytical functions such as cellular statistical analysis, subcellular localization, protein colocalization, forward and reverse tracking, cell subpopulation classification, and cell tracking.
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Imaging mode |
Fluorescence imaging (free combination of X, Y, Z, T, and λ), bright-field imaging, and DIC imaging |
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Ultra-high resolution |
8192×8192, Confocal XY: 90 nm, Z: 300 nm; Structured Illumination SIM XY: 80 nm, Z: 300 nm |
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Imaging speed |
Conventional scanning at 12 frames per second (at 512 × 512), optionally paired with a resonant scanning galvanometer, enabling imaging speeds of up to 32 frames per second; structured-light SIM at 50 fps at 512 × 512 pixels. |
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Excitation light source |
405 nm, 445 nm, 488 nm, 520 nm, 561 nm, 594 nm, 640 nm, 730 nm, 785 nm, etc. (standard configuration includes four wavelengths; multiple options available in the upgraded version) |
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Probe |
Four PMTs, with at least two GaAsP types and a quantum efficiency of ≥45%, compatible with multiple detectors including multialkali PMTs, GaAsP, GaAs, and SiPMs; maximum detection wavelength: 900 nm. |
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Rotational scanning |
Rotational scanning angle: 0–360°, with an adjustment resolution of 0.1°; during rotational scanning, differential interference contrast imaging can be performed simultaneously. |
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Spectral scanning |
All fluorescence detectors can perform linear spectral scanning, spectral scanning, and spectral deconvolution; spectral resolution is 1 nm. |
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Microscopic objective lens |
Plan-Apochromat Confocal-Specific Objective Lens 10X: N.A. : 0.4 20X: N.A. : 0.8 40X: N.A.: 0.95 60X: N.A.: 1.42 Oil immersion objective 100X: N.A.: 1.45 Oil immersion objective |
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Microscope main unit |
All-electric, research-grade inverted fluorescence microscope (Nikon Ti2‑E, Olympus Ix83, or a domestically produced option) |
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Imaging function |
Sample two-dimensional imaging, three-dimensional imaging, large-field-of-view mosaic imaging, live-cell time-lapse imaging, and more; supports a grating-based spectroscopic system for high-precision, high-linearity spectral scanning, detection, and separation. |
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Post-processing function |
Deconvolution, 3D reconstruction, image enhancement, colocalization, cell subpopulation classification, AI‑based cell segmentation, cell tracking, and more. |
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Analysis Function |
Interactive measurement functions, automated cell identification, single-cell quantitative analysis, subcellular structure analysis, fluorescence colocalization analysis, and AI‑based automated analysis and measurement capabilities, among others. |
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Imaging modality |
Supports bright-field imaging, wide-field fluorescence imaging, and TIRF wide-field imaging; as well as wide-field-SIM, TIRF-SIM, 2D-SIM stack, 3D-SIM stack, real-time SIM, and spinning-disk confocal imaging. |
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Compatible with spinning-disk confocal systems |
Optional configurations include the YOKOGAWA CSU-W1 spinning-disk confocal system, the Crestoptics CICERO spinning-disk confocal system, and others. |
* The processing and analysis software is 100% developed in-house, not third-party software, and can all be installed offline.
* Product performance is continuously being iterated, and customized development requirements for both hardware and software are acceptable. The manufacturer retains the authority to interpret performance parameters.
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• Keywords:
Laser scanning confocal microscope,Microscope
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