Changyi Guangke (Suzhou) Technology Co., Ltd.

Changyi Guangke, headquartered in the Suzhou Industrial Park of the China (Jiangsu) Pilot Free Trade Zone, maintains branch offices in Xi’an and Qingdao. As a high-tech enterprise specializing in micro‑ and nano‑scale optical imaging and the R&D and manufacturing of advanced optical instruments, Changyi Guangke is one of the few domestic manufacturers that independently develops software, hardware, and underlying components across the entire technology stack.

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Laser Confocal Microscope

MEAGLE 100

Laser Confocal Microscope


120 nm ultra-high optical resolution Fastest imaging speed of 12 fps 8192×8192 high‑quality scanning pixels

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Product Introduction

The MEAGLE 100 is a versatile confocal microscope independently developed, manufactured, and marketed by Changyi Guangke as a replacement for traditional fluorescence microscopes. With an ultra‑high‑resolution optical resolution of up to 120 nm, the MEAGLE 100 delivers imaging speeds of up to 12 frames per second and supports scan resolutions as high as 8192 × 8192. Its features—including high light‑source utilization, exceptional sensitivity, and low phototoxicity—ensure stable, high‑definition imaging over extended periods.

The MEAGLE 100 is equipped with multiple high-precision motion modules, enabling a variety of imaging modes, including motorized focusing, three-dimensional scanning, and automated large‑field stitching. Post‑processing analysis bridges the gap between qualitative and quantitative observations; the system not only offers an extensive suite of post‑processing tools—such as deconvolution, image enhancement, image smoothing, morphological processing, and feature segmentation—but also provides advanced scene‑specific analysis capabilities, including cellular statistical analysis, subcellular localization, protein‑protein colocalization, forward and reverse tracking, cell subpopulation classification, and cell tracking.

The MEAGLE 100 is a versatile confocal microscope independently developed, manufactured, and marketed by Changyi Guangke as a replacement for traditional fluorescence microscopes. With an ultra‑high‑resolution optical resolution of up to 120 nm, the MEAGLE 100 delivers imaging speeds of up to 12 frames per second and supports scan resolutions as high as 8192 × 8192. Its features—including high light‑source utilization, exceptional sensitivity, and low phototoxicity—ensure stable, high‑definition imaging over extended periods.

The MEAGLE 100 is equipped with multiple high-precision motion modules, enabling a variety of imaging modes, including motorized focusing, three-dimensional scanning, and automated large‑field stitching. Post‑processing analysis bridges the gap between qualitative and quantitative observations; the system not only offers an extensive suite of post‑processing tools—such as deconvolution, image enhancement, image smoothing, morphological processing, and feature segmentation—but also provides advanced scene‑specific analysis capabilities, including cellular statistical analysis, subcellular localization, protein‑protein colocalization, forward and reverse tracking, cell subpopulation classification, and cell tracking.

Laser Confocal Microscope

 

ConfigurationDescription

Imaging mode

Fluorescence imaging (free combination of X, Y, Z, T, and λ), bright-field imaging, and DIC imaging

Ultra-high resolution

8192*8192 XY: 120 nm Z: 300 nm

Imaging speed

12 frames per second (@512 × 512), with a resonant scanning galvanometer capable of even higher rates.

Excitation light source

405 nm, 445 nm, 488 nm, 520 nm, 561 nm,

639 nm, 785 nm, etc. (standard configuration includes four wavelengths; multiple options available in the upgraded version)

Probe

≥4 PMTs, upgradeable to GaAsP type, quantum efficiency 45%

Microscopic objective lens

Plan-Apochromat Confocal-Specific Objective Lens

10X: N.A. : 0.45

20X: N.A. : 0.80

40X: N.A.: 0.95

60X: N.A.: 1.42 Oil immersion objective

100X: N.A.: 1.45 Oil immersion objective

Microscope main unit

All-electric, research-grade inverted fluorescence microscope

(Nikon Ti2‑E, Olympus Ix83, or a domestically produced option)

Imaging function

Sample two-dimensional imaging, three-dimensional imaging, large-field-of-view mosaic imaging, live-cell time-lapse imaging, and more.

Post-processing function

Deconvolution, 3D reconstruction, image enhancement, colocalization, cell subpopulation classification, AI‑based cell segmentation, cell tracking, and more.

Analysis Function

Interactive measurement functions, automated cell identification, single-cell quantitative analysis,

Subcellular structure analysis, fluorescence colocalization analysis, AI‑based automated analysis and measurement capabilities, and more.

* The processing and analysis software is 100% developed in-house, not third-party software, and can all be installed offline.

* Product performance is continuously being iterated, and customized development requirements for both hardware and software are acceptable. The manufacturer retains the authority to interpret performance parameters.


• Keywords:

Laser,Subcellular Structure Analysis,Fast imaging speed

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